p-Anisoyl chloride → 5-(4-Anisamido)-3-Trichloromethyl-1,2,4-Thiadiazole

HRID 66938

反応式

HRID 66938 の反応式
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1.[C:11](Cl)(=[O:20])[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1>C1(C)C(C)=CC=CC=1>[C:11]([NH:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1)(=[O:20])[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 7477p-Anisoyl chlorideHCID 6028483-(Trichloromethyl)-1,2,4-thiadiazol-5-amine

生成物 1

HCID 130415175-(4-Anisamido)-3-Trichloromethyl-1,2,4-Thiadiazole

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

A solution of 11.0 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 12.8 g (0.08 mole) 4-anisoyl chloride in 200 ml xylene was heated at reflux for 20 hours. Cooling of the reaction mixture resulted in precipitation of the crude product, which was then isolated by filtration. Purification was achieved by washing the crude product with hot hexane. Yield was 12.0 g (82%); m.p. 172° C.

後処理

  1. temperatureat reflux for 20 hours
  2. temperatureCooling of the reaction mixture

出典と根拠

ORDレコード
ord-c5e879964bea48bfb1cb9bbca35b987c
出典データセット
uspto-grants-1982_08
特許番号
US04343945

関連ノート

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