Pyridine → 3-Triphenylmethoxy-1-octyne

HRID 66988

反応式

HRID 66988 の反応式
[CH:1]#[C:2][CH:3]([OH:9])[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[C:10]1([C:16](Br)([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.N1C=CC=CC=1.[K+].[Br-]>O>[C:10]1([C:16]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[O:9][CH:3]([CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[C:2]#[CH:1])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

6

反応物 4

HCID 1049PyridineHCID 11692BromotriphenylmethaneHCID 131661-Octyn-3-olHCID 253877Potassium Bromide

生成物 1

HCID 126753473-Triphenylmethoxy-1-octyne

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 1.26 g. (10.0 mmoles) of 1-octyn-3-ol, 4.85 g. (15.0 mmoles) of triphenylmethyl bromide, and 50 ml. of dry pyridine is heated at 95° C. for 60 minutes with occasional swirling. The solution is cooled, treated with water, and extracted with ether. The extract is washed successively with water and saturated sodium chloride solution, dried over magnesium sulfate, and concentrated. The crude product is purified by chromatography on Florisil and recrystallization from petroleum ether to give white crystals, m.p. 65°-66.5°, ν max. (KBr) 3280 (acetylenic hydrogen), 1605, 1030, and 702 cm-1 (triphenylmethoxy group).

後処理

  1. additionA mixture of 1.26 g
  2. temperatureThe solution is cooled
  3. extractionextracted with ether
  4. washThe extract is washed successively with water and saturated sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated
  7. customThe crude product is purified by chromatography on Florisil and recrystallization from petroleum ether
  8. customto give white crystals, m.p. 65°-66.5°, ν max

出典と根拠

ORDレコード
ord-3e964eb3d945459f83319c5b49610467
出典データセット
uspto-grants-1982_08
特許番号
US04343949

関連ノート

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