Sodium Iodide → (E)-1-Iodo-1-octen-3-one

HRID 66998

反応式

HRID 66998 の反応式
[I-:1].[Na+].Cl/[CH:4]=[CH:5]/[C:6](=[O:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]>CC(C)=O>[I:1]/[CH:4]=[CH:5]/[C:6](=[O:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 110410031-Chloro-trans-1-octen-3-one

生成物 1

HCID 11139597(E)-1-Iodo-1-octen-3-one

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 54.5 g. (0.364 mole) of sodium iodide and 40 g. (0.249 mole) of 1-chloro-trans-1-octen 3-one (Example 723) in 360 ml. of acetone is stirred and refluxed for 24 hours. The reaction mixture is cooled, filtered and concentrated. The residue is partitioned between water and ether. The organic phase is washed with dilute sodium bicarbonate solution, brine, dried (MgSO4) and evaporated to an oil. This material is used directly without purification.

後処理

  1. additionA mixture of 54.5 g
  2. temperaturerefluxed for 24 hours
  3. temperatureThe reaction mixture is cooled
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe residue is partitioned between water and ether
  7. washThe organic phase is washed with dilute sodium bicarbonate solution, brine
  8. dry with materialdried (MgSO4)
  9. customevaporated to an oil
  10. customThis material is used directly without purification

出典と根拠

ORDレコード
ord-cc5a5bc568654d7fbe216c594475e448
出典データセット
uspto-grants-1982_08
特許番号
US04343949

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