Sodium borohydride → 1-Bromo-trans-1-octen-3-ol
反応式
[BH4-].[Na+].[Br:3]/[CH:4]=[CH:5]/[C:6](=[O:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].Cl/C=C/C(=O)CCCCC>C(O)C>[Br:3]/[CH:4]=[CH:5]/[CH:6]([OH:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]参加物
5
実験手順
To an ice cooled mixture of 14.29 g. (0.378 mole) of sodium borohydride in 400 ml. of anhydrous ethanol is added the crude 1-bromo-trans-1-octen-3-one (Example 725), from 0.424 mole of 1-chloro-trans-1-octen-3-one) over 30 minutes. The mixture is stirred for 2 hours with ice cooling and is then partitioned between ice water and benzene. The organic phase is washed with water and saturated brine, dried (Na2SO4), and evaporated to an oil. Fractional distillation yields the title compound as a colorless oil, b.p. 66°-68° C. (0.025 torr).
後処理
- additionmixture of 14.29 g
- customis then partitioned between ice water and benzene
- washThe organic phase is washed with water and saturated brine
- dry with materialdried (Na2SO4)
- customevaporated to an oil
- distillationFractional distillation
出典と根拠
- ORDレコード
- ord-7ccd459c441e4a12a41d3f3fa207264e
- 出典データセット
- uspto-grants-1982_08
- 特許番号
- US04343949
反応ノート
読み込み中…