Sodium borohydride → 1-Bromo-trans-1-octen-3-ol

HRID 67009

反応式

HRID 67009 の反応式
[BH4-].[Na+].[Br:3]/[CH:4]=[CH:5]/[C:6](=[O:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]>C(O)C>[Br:3]/[CH:4]=[CH:5]/[CH:6]([OH:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 117903381-Bromo-trans-1-octen-3-one

生成物 1

HCID 130462801-Bromo-trans-1-octen-3-ol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To an ice cooled mixture of 20 g. of sodium borohydride in 800 ml. of anhydrous ethanol is added 160 g. of crude 1-bromo-trans-1-octen-3-one (Example 992) over a period of 0.5 hour. The mixture is stirred for 2 hours with ice cooling and is then partitioned between ice water and benzene. The organic phase is washed with water and saturated brine, dried (Na2SO4), and evaporated to an oil. Distillation gives the product as an oil, b.p. 66°-68° C. (0.025 torr.).

後処理

  1. additionmixture of 20 g
  2. customis then partitioned between ice water and benzene
  3. washThe organic phase is washed with water and saturated brine
  4. dry with materialdried (Na2SO4)
  5. customevaporated to an oil
  6. distillationDistillation

出典と根拠

ORDレコード
ord-9cd4942eecd649598de0cd794a0a2a0a
出典データセット
uspto-grants-1982_08
特許番号
US04343949

関連ノート

読み込み中…