Thionyl Chloride → 6,7-Dihydroxy-4-oxo-4H-1-benzopyran-3-carbonyl chloride

HRID 67094ノート

反応式

HRID 67094 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][CH:7]=[C:6]([C:13](O)=[O:14])[C:5]2=[O:16].S(Cl)([Cl:19])=O>>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][CH:7]=[C:6]([C:13]([Cl:19])=[O:14])[C:5]2=[O:16]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 122007766,7-Dihydroxychromon-3-carboxylic acid

生成物 1

HCID 127657576,7-Dihydroxy-4-oxo-4H-1-benzopyran-3-carbonyl chloride

実験手順

6,7-Dihydroxychromon-3-carboxylic acid (888 mg) together with thionyl chloride (25 ml) were refluxed for one hour. Any unreacted thionyl chloride was then removed from the reaction mixture by distillation. Benzene was added to the residue, and the mixture was subjected to distillation. The residue was triturated with dichloromethane to obtain the desired product (719 mg).

後処理

  1. customAny unreacted thionyl chloride was then removed from the reaction mixture by distillation
  2. additionBenzene was added to the residue
  3. distillationthe mixture was subjected to distillation
  4. customThe residue was triturated with dichloromethane

出典と根拠

ORDレコード
ord-64df3025169449458472a78897e73697
出典データセット
uspto-grants-1982_08
特許番号
US04344944

反応ノート

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