Hydrochloric Acid → 1-(3-Phenoxyphenyl)prop-2-en-1-ol

HRID 67121

反応式

HRID 67121 の反応式
[CH:1]([Mg]Cl)=[CH2:2].[O:5]([C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=1)[CH:15]=[O:16])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[Cl-].[NH4+].Cl>O1CCCC1>[O:5]([C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=1)[CH:15]([OH:16])[CH:1]=[CH2:2])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 382843-PhenoxybenzaldehydeHCID 178461836HCID 178461836、化合物

生成物 1

HCID 129613931-(3-Phenoxyphenyl)prop-2-en-1-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒3 回

実験手順

30 ml of a 1.6 molar solution of vinyl-magnesium chloride in tetrahydrofuran are introduced into 100 ml of absolute tetrahydrofuran at 0° C. 9.8 g (0.05 mole) of 3-phenoxybenzaldehyde in 100 ml of absolute tetrahydrofuran are added dropwise whilst stirring and excluding moisture. The reaction mixture is stirred for 3 hours at 25° C. and is then cautiously decomposed by adding a cold saturated ammonium chloride solution and a few milliliters of 10% strength hydrochloric acid until the precipitate dissolves. The mixture is then extracted three times by shaking with ether and the combined ether extracts are washed with sodium bisulfite solution, sodium bicarbonate solution and water, dried over sodium sulfate and concentrated under reduced pressure.

後処理

  1. stirringThe reaction mixture is stirred for 3 hours at 25° C.
  2. dissolutiondissolves
  3. extractionThe mixture is then extracted three times
  4. stirringby shaking with ether
  5. washthe combined ether extracts are washed with sodium bisulfite solution, sodium bicarbonate solution and water
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-c02e0b0696244eaba1e6f3e9c3e9d914
出典データセット
uspto-grants-1982_08
特許番号
US04344961

関連ノート

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