Nitrofungin → 4-Amino-2-chlorophenol

HRID 67157

反応式

HRID 67157 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[OH:11].[H][H]>O1CCCC1.[Ni]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([OH:11])=[C:2]([Cl:1])[CH:7]=1

参加物

5

反応物 2

HCID 12074NitrofunginHCID 178418361HCID 178418361、化合物

生成物 1

HCID 775784-Amino-2-chlorophenol

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 86.8 g of 2-chloro-4-nitrophenol in 200 ml of tetrahydrofuran containing 2 g of Raney nickel catalyst was hydrogenated in a Parr shaker at 50 p.s.i. hydrogen pressure. The mixture was filtered and the solvent was evaporated from the filtrate. The residue was recrystallized from ether to give 4-amino-2-chlorophenol (1A), as a tan solid, mp: 144°-147° C.

後処理

  1. filtrationThe mixture was filtered
  2. customthe solvent was evaporated from the filtrate
  3. customThe residue was recrystallized from ether

出典と根拠

ORDレコード
ord-67c7ef7a201648e7a36113cb54725f0d
出典データセット
uspto-grants-1982_08
特許番号
US04345076

関連ノート

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