Nitrofungin → 4-Amino-2-chlorophenol
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[OH:11].[H][H]>O1CCCC1.[Ni]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([OH:11])=[C:2]([Cl:1])[CH:7]=1参加物
5
実験手順
A solution of 86.8 g of 2-chloro-4-nitrophenol in 200 ml of tetrahydrofuran containing 2 g of Raney nickel catalyst was hydrogenated in a Parr shaker at 50 p.s.i. hydrogen pressure. The mixture was filtered and the solvent was evaporated from the filtrate. The residue was recrystallized from ether to give 4-amino-2-chlorophenol (1A), as a tan solid, mp: 144°-147° C.
後処理
- filtrationThe mixture was filtered
- customthe solvent was evaporated from the filtrate
- customThe residue was recrystallized from ether
出典と根拠
- ORDレコード
- ord-67c7ef7a201648e7a36113cb54725f0d
- 出典データセット
- uspto-grants-1982_08
- 特許番号
- US04345076
反応ノート
読み込み中…