Triphenylphosphine → (3-(1,3-Dioxoisoindolin-2-yl)propyl)triphenylphosphonium bromide

HRID 6716

反応式

HRID 6716 の反応式
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:20][CH2:21][CH2:22][CH2:23][N:24]1[C:28](=[O:29])[C:27]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:26]2[C:25]1=[O:34]>C1(C)C=CC=CC=1>[Br-:20].[C:25]1(=[O:34])[N:24]([CH2:23][CH2:22][CH2:21][P+:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:28](=[O:29])[C:27]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:26]12

参加物

4

反応物 2

HCID 11776TriphenylphosphineHCID 21611N-3-Bromopropylphthalimide

生成物 1

HCID 22018487(3-(1,3-Dioxoisoindolin-2-yl)propyl)triphenylphosphonium bromide収率 46.1%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

The 3-phthalimidopropyltriphenylphosphonium bromide was prepared as follows. To a solution of triphenylphosphine (24.5 g, Aldrich, U.S.A.) in toluene (200 mL) was added N-(3-bromopropyl)phthalimide (25 g, Aldrich, U.S.A.). The mixture was heated to reflux overnight. The white solid so formed was isolated by filtration and dried under vacuum to yield 3-phthalimidopropyltriphenylphosphonium bromide (22.8 g).

後処理

  1. customThe 3-phthalimidopropyltriphenylphosphonium bromide was prepared
  2. temperatureThe mixture was heated
  3. temperatureto reflux overnight
  4. customThe white solid so formed
  5. customwas isolated by filtration
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-e96b0f6e3a4f4f18982b5bc493f3a1d2
出典データセット
uspto-grants-2006_08
特許番号
US07084154B2

関連ノート

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