3-Nitro-p-cresol → 3-Amino-p-cresol

HRID 67162

反応式

HRID 67162 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([OH:11])[CH:7]=[CH:8][C:9]=1[CH3:10])([O-])=O.[H][H]>[Ni].O1CCCC1>[NH2:1][C:4]1[CH:5]=[C:6]([OH:11])[CH:7]=[CH:8][C:9]=1[CH3:10]

参加物

5

反応物 2

HCID 162713-Nitro-p-cresolHCID 178418361HCID 178418361、化合物

生成物 1

HCID 178203-Amino-p-cresol

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒

実験手順

70 g of 3-nitro-4-methylphenol, prepared according to German Offenalegungschrift No. 2,213,568, 200 ml of tetrahydrofuran and 2 g of activated Raney nickel catalyst were placed in a Parr bomb. The mixture was shaken for 3.5 hours under 60 p.s.i. hydrogen pressure. The mixture then was filtered and the solvent was evaporated from the filtrate. The residue was recrystallized from ether to give 3-amino-4-methylphenol (3A), as a grey solid, mp: 145°-148° C.

後処理

  1. filtrationThe mixture then was filtered
  2. customthe solvent was evaporated from the filtrate
  3. customThe residue was recrystallized from ether

出典と根拠

ORDレコード
ord-2a417ce8477b47ffb0400faad8e9f2d7
出典データセット
uspto-grants-1982_08
特許番号
US04345077

関連ノート

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