Sarcosine → N-methyl-N-carboxymethyl-N'-phenylurea

HRID 67244

反応式

HRID 67244 の反応式
[CH3:1][NH:2][CH2:3][C:4]([OH:6])=[O:5].[OH-].[Na+].[C:9]1([N:15]=[C:16]=[O:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>O>[CH3:1][N:2]([CH2:3][C:4]([OH:6])=[O:5])[C:16]([NH:15][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:17]

参加物

5

反応物 3

HCID 1088SarcosineHCID 7672Phenyl isocyanateHCID 14798Sodium Hydroxide

生成物 1

HCID 13052256N-methyl-N-carboxymethyl-N'-phenylurea

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
24 °C

実験手順

To a stirred solution of 70 g. of N-methylaminoacetic acid in 500 ml. of water containing 70 g. of sodium hydroxide were added portion-wise over twenty minutes 100 g. of phenyl isocyanate. Following complete addition, the aqueous reaction mixture was stirred at 24° C. for two hours. The mixture was then filtered and the filtrate was acidified to pH 2 by the addition of conc. hydrochloric acid. The precipitate which formed was collected by filtration to provide N-methyl-N-hydroxycarbonylmethyl-N'-phenylurea.

後処理

  1. additionaddition
  2. filtrationThe mixture was then filtered
  3. additionthe filtrate was acidified to pH 2 by the addition of conc. hydrochloric acid
  4. customThe precipitate which formed
  5. filtrationwas collected by filtration

出典と根拠

ORDレコード
ord-f3856926245047b18dba8d48c55b3f7b
出典データセット
uspto-grants-1982_08
特許番号
US04345936

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