Hydrochloric Acid → 2-Amino-6-fluorobenzoic acid hydrochloride

HRID 67352

反応式

HRID 67352 の反応式
[F:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([N+:11]([O-])=O)[CH:5]=[CH:4][CH:3]=1.[ClH:14]>CO.[Pd]>[ClH:14].[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([NH2:11])[C:7]=1[C:8]([OH:10])=[O:9]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 6037582-Fluoro-6-nitrobenzoic acid

生成物 1

HCID 250673672-Amino-6-fluorobenzoic acid hydrochloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

2.7 g of 10 percent palladium/carbon are added to a solution of 20.0 g (0.108 mol) of 6-fluoro-nitrobenzoic acid in a mixture of 200 ml of methanol and 27 ml of concentrated hydrochloric acid and the resulting mixture is hydrogenated at 35°-40° C. under a slight over-pressure. After filtration of the catalyst and concentration of the filtrate, the crude product is recrystallised from methanol/ether. There is obtained 6-fluoroanthranilic acid hydrochloride of melting point 176°-178° C. (decomposition).

後処理

  1. customis hydrogenated at 35°-40° C. under a slight over-pressure
  2. filtrationAfter filtration of the catalyst and concentration of the filtrate
  3. customthe crude product is recrystallised from methanol/ether

出典と根拠

ORDレコード
ord-f75fddb8730846758916ad4a1bcb349a
出典データセット
uspto-grants-1982_08
特許番号
US04346031

関連ノート

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