Tetrahydrofuran → 1H-Indol-3-Ylmethanamine
反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[NH:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([C:16]#[N:17])=[CH:8]1.O1CCCC1>O1CCOCC1>[NH:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([CH2:16][NH2:17])=[CH:8]1参加物
5
実験手順
Lithium aluminum hydride (100 mg) was added to a solution of 1H-indole-3-carbonitrile (100 mg) in 15 mL of 2:1 dioxane:tetrahydrofuran. The mixture was refluxed for 0.5 h, then cooled to 0 C and quenched by the sequential addition of 0.1 mL water, 0.1 mL 3 N sodium hydroxide, and 0.3 mL more water. After the mixture was stirred for 15 min at rt, the aluminum salts were removed by filtration and the solvent was evaporated to give 56 mg of C-(1H-indol-3-yl)methylamine.
後処理
- temperatureThe mixture was refluxed for 0.5 h
- temperaturecooled to 0 C
- customquenched by the sequential addition of 0.1 mL water, 0.1 mL 3 N sodium hydroxide, and 0.3 mL more water
- customthe aluminum salts were removed by filtration
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-51057ba33ac843df960a60de27fd9d4c
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07084154B2
反応ノート
読み込み中…