Dichloromethane → N-(4-tert-Butyl-phenyl)-6-piperazin-1-yl-nicotinamide

反応式

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][cH:16][c:17]([C:20]([NH:21][c:22]3[cH:23][cH:24][c:25]([C:28]([CH3:29])([CH3:30])[CH3:31])[cH:26][cH:27]3)=[O:32])[cH:18][cH:19]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:40][CH2:41][Cl:42].[F:33][C:34]([F:35])([F:36])[C:37]([OH:38])=[O:39]>>[NH:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][cH:16][c:17]([C:20]([NH:21][c:22]3[cH:23][cH:24][c:25]([C:28]([CH3:29])([CH3:30])[CH3:31])[cH:26][cH:27]3)=[O:32])[cH:18][cH:19]2)[CH2:12][CH2:13]1

参加物

反応物 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 593180214-[5-(4-tert-Butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 59318019N-(4-tert-Butyl-phenyl)-6-piperazin-1-yl-nicotinamide

出典と根拠

ORDレコード: ord-f8f2c78a3608431ebdf1314d07f4d695
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…