Lauric Acid → 4-lauramidoethyl-6-methyl-3,6-dihydro-2H-1,4-diazepin-5-one
反応式
[NH2:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH2:7].[CH:8]([CH:10]([CH3:15])[C:11]([O:13]C)=O)=O.[C:16](O)(=[O:28])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]>>[C:16]([NH:1][CH2:2][CH2:3][N:4]1[C:11](=[O:13])[CH:10]([CH3:8])[CH:15]=[N:7][CH2:6][CH2:5]1)(=[O:28])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]参加物
4
実験手順
Into an apparatus similar to that in Example 1, were charged 103.1 g (1 mole) of diethylenetriamine and 116.1 g (1 mole) of methyl 2-formylpropionate. At 130° to 135° C., 18 g of water and 32 g of methanol were distilled off. Then, after addition of 200.3 g (1 mole) of lauric acid, the amide formation was effected at 200° to 210° C. to distil off 18 g of water, leaving behind 4-lauramidoethyl-6-methyl-3,6-dihydro-2H-1,4-diazepin-5-one.
後処理
- distillation