1,2,4-Trichlorobenzene → 2,4,5-Trichloronitrobenzene

2723 gm (15.0 mols) of 1,2,4-trichlorobenzene were added to 7350 gm (105 mols) of 90% fuming nitric acid at 40° C. over a 3 hour period. The reaction mixture was held at 40° C. for one hour and worked up by the addition of 3700 ml of H2O while maintaining a temperature of 55°-60° C., and separating the waste acid. Two additional washes with 2000 ml of hot (55° C.) water and 1000 ml of 10% sodium bicarbonate solution followed by a phase separation gave 3316 gm (14.64 mols) of crude 1,2,4-trichloro-5-nitrobenzene. An additional 33 gm product was recovered from the waste acid when cooled and filtered.

1. customat 40° C.
2. customover a 3 hour
3. temperaturewhile maintaining a temperature of 55°-60° C.
4. customseparating the waste acid
5. customTwo additional washes with 2000 ml of hot (55° C.) water and 1000 ml of 10% sodium bicarbonate solution followed by a phase separation

ORDレコード

ord-e53549ce01a2493a96142624339f6386

出典データセット

uspto-grants-1982_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04346248