Cysteamine → 6-Methyl-3-pyridylmethyl-4-pyrimidone

HRID 67878

反応式

HRID 67878 の反応式
C[N:2]([CH2:4][C:5]1O[C:8]([CH2:10]O)=[CH:7][CH:6]=1)[CH3:3].CN(CC1[O:20]C(CSCCN)=CC=1)C.NCCS.[NH2:30][CH2:31][CH2:32][C:33]1[N:37]=CN[CH:34]=1.[H][H]>C(O)(=O)C>[CH3:34][C:33]1[N:37]=[C:10]([CH2:8][C:7]2[CH:3]=[N:2][CH:4]=[CH:5][CH:6]=2)[NH:30][C:31](=[O:20])[CH:32]=1

参加物

6

反応物 4

HCID 6058CysteamineHCID 849065-((Dimethylamino)methyl)-2-furanmethanolHCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 178510869HCID 178510869、化合物

生成物 1

HCID 1361872966-Methyl-3-pyridylmethyl-4-pyrimidone

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

5-Dimethylaminomethyl-2-furanmethanol can be converted into 2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamine by heating under reflux in acetic acid with cysteamine and can be further converted into various histamine H2 -antagonists for example, by reacting with a substituted pyrimidone to give 2-2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamino-5-(6-methyl-3-pyridylmethyl-4-pyrimidone by methods described in EP 3677.

後処理

  1. temperatureby heating

出典と根拠

ORDレコード
ord-3bde087f247843d19e16bfe9b8309d82
出典データセット
uspto-grants-1982_08
特許番号
US04347191

関連ノート

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