6-Nitro-2-piperidin-1-ylquinoline → 2-Piperidin-1-ylquinolin-6-amine

HRID 6796

反応式

HRID 6796 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[CH:8]=[CH:7]2)([O-])=O>CO.[OH-].[OH-].[Pd+2]>[N:14]1([C:9]2[CH:8]=[CH:7][C:6]3[C:11](=[CH:12][CH:13]=[C:4]([NH2:1])[CH:5]=3)[N:10]=2)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1

参加物

4

反応物 1

HCID 220189706-Nitro-2-piperidin-1-ylquinoline

生成物 1

HCID 220189742-Piperidin-1-ylquinolin-6-amine

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

The product (204 mg, 0.8 mmol) of Step C and palladium hydroxide on carbon (100 mg) was suspended in methanol. The resulting mixture was degassed then stirred under hydrogen atmosphere (balloon) until all the yellow solids had dissolved. The reaction mixture was filtered through filter aid and the solvent removed under vacuum to afford the product as a brown solid, MS: m/z 228 (MH+), which was used without further purification

後処理

  1. customThe resulting mixture was degassed
  2. dissolutionhad dissolved
  3. filtrationThe reaction mixture was filtered
  4. filtrationthrough filter aid
  5. customthe solvent removed under vacuum

出典と根拠

ORDレコード
ord-7a8c29af5c6d4ed5850e6a506f148c64
出典データセット
uspto-grants-2006_08
特許番号
US07084156B2

関連ノート

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