Dimethylformamide → (2E)-3-(4-Chlorophenyl)acryloyl chloride

HRID 6797

反応式

HRID 6797 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([OH:12])=O)=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:16])=O.CN(C)C=O>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([Cl:16])=[O:12])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 6377974-Chlorocinnamic acid

生成物 1

HCID 11252649(2E)-3-(4-Chlorophenyl)acryloyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (2E)-3-(4-chlorophenyl)prop-2-enoic acid (2.0 g, 11 mmol) in 50 mL methylene chloride was added oxalyl chloride (1.05 mL, 12.1 mmol) and N,N-dimethylformamide (0.05 mL, 0.6 mmol). The resulting mixture was stirred at r.t. for 6 h. The solvent was removed under vacuum. The resulting solid was diluted with hexanes and the solvent removed under vacuum to provide an off-white solid which was used without further purification.

後処理

  1. customThe solvent was removed under vacuum
  2. additionThe resulting solid was diluted with hexanes
  3. customthe solvent removed under vacuum
  4. customto provide an off-white solid which
  5. customwas used without further purification

出典と根拠

ORDレコード
ord-98ba0a4789094cd8bd645b484b6e0ba8
出典データセット
uspto-grants-2006_08
特許番号
US07084156B2

関連ノート

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