1,3-Dichloroacetone → HCID 178479412、化合物

HRID 67976

反応式

HRID 67976 の反応式
[C:1]([NH:4][C:5]([NH2:7])=[S:6])(=[NH:3])[NH2:2].[Cl:8][CH2:9][C:10]([CH2:12]Cl)=O>CC(C)=O>[ClH:8].[NH:4]([C:5]1[S:6][CH:12]=[C:10]([CH2:9][Cl:8])[N:7]=1)[C:1]([NH2:2])=[NH:3]

参加物

4

反応物 2

HCID 107931,3-DichloroacetoneHCID 178513045HCID 178513045、化合物

生成物 1

HCID 178479412HCID 178479412、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

A suspension of amidinothiourea (16.8 g.) in acetone (75 ml.) was treated with 1,3-dichloroacetone (18 g.) in acetone (60 ml.). There was a slight exotherm and the crystalline suspension gradually changed to a fine white solid. After stirring overnight at room temperature the solid was filtered off and washed with acetone. Crystallization from ethanol gave 2-guanidino-4-chloromethylthiazole hydrochloride, m.p. 191°-193° C.

後処理

  1. filtrationwas filtered off
  2. washwashed with acetone
  3. customCrystallization from ethanol

出典と根拠

ORDレコード
ord-8f0590970f954d00939dac7949961f7e
出典データセット
uspto-grants-1982_08
特許番号
US04347370

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