Ethyl Glycolate → Ethoxycarbonylmethyl 3-phenylpropanoate

HRID 68009

反応式

HRID 68009 の反応式
[C:1](Cl)(=[O:10])[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C:12]([O:16][CH2:17][CH3:18])(=[O:15])[CH2:13][OH:14]>N1C=CC=CC=1>[C:1]([O:14][CH2:13][C:12]([O:16][CH2:17][CH3:18])=[O:15])(=[O:10])[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 12184Ethyl GlycolateHCID 64801Benzenepropanoyl chloride

生成物 1

HCID 321703Ethoxycarbonylmethyl 3-phenylpropanoate

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

33.7 g (0.2 mole) of hydrocinnamoyl chloride was added to a stirred solution of 18 g (0.2 mole) of ethyl glycolate in 20 ml of pyridine. The precipitated pyridine hydrochloride was filtered, washed with benzene, and discarded. The benzene solution of carboethoxymethyl hydrocinnamate was water washed, dried over sodium sulfate, and the solvent stripped off using a rotary evaporator. The yield of product was essentially quantitative. Its structure was established by infrared and nuclear magnetic resonance spectroscopy. It had nD30 1.4900 and d430 1.0919.

後処理

  1. filtrationThe precipitated pyridine hydrochloride was filtered
  2. washwashed with benzene
  3. washwashed
  4. dry with materialdried over sodium sulfate
  5. customa rotary evaporator

出典と根拠

ORDレコード
ord-0bc7aad0b1304a1690b89b3371a5b570
出典データセット
uspto-grants-1982_08
特許番号
US04347378

関連ノート

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