Thionyl Chloride → 3-tert-Butyldimethylsilyloxybenzoyl chloride

HRID 68213ノート

反応式

HRID 68213 の反応式
[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12](O)=[O:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].S(Cl)([Cl:20])=O>>[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([Cl:20])=[O:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 183695873-{[tert-Butyl(dimethyl)silyl]oxy}benzoic acid

生成物 1

HCID 124484873-tert-Butyldimethylsilyloxybenzoyl chloride

実験手順

Into a 100 mL round bottom flask a mixture of 5 parts of 3-tert-butyldimethylsilyloxybenzoic acid and 25 mL of thionyl chloride was heated at reflux for 90 mins. The reaction mixture was concentrated under reduced pressure to give an oil, yield 5.77 parts of the following structure.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 90 mins
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customto give an oil
  5. customyield 5.77 parts of the following structure

出典と根拠

ORDレコード
ord-aac3b60ce93f439490fc389da096672e
出典データセット
uspto-grants-2014_09
特許番号
US08822233B2

反応ノート

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