Sodium Hydroxide → 4-(4-Methyloxazol-5-yl)benzoic acid

HRID 68761ノート

反応式

HRID 68761 の反応式
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][CH:13]=[N:12][C:11]=2[CH3:15])=[CH:6][CH:5]=1.[OH-].[Na+]>CO>[CH3:15][C:11]1[N:12]=[CH:13][O:14][C:10]=1[C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:16])=[O:2])=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 682895774-(4-Methyl-oxazol-5-yl)-benzoic acid methyl ester

生成物 1

HCID 682900554-(4-Methyloxazol-5-yl)benzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 4-(4-methyl-oxazol-5-yl)-benzoic acid methyl ester (1.50 g), 1 M aqueous NaOH solution (7.00 mL) and methanol (20 mL) is kept at room temperature overnight. The precipitate is filtered off, dissolved in water and neutralized with 4 M HCl. The precipitate is filtered off, dissolved in dichloromethane and a small amount of methanol, and the solution is dried over Na2SO4 and concentrated in vacuo. The residue is triturated with diethylether to afford the title compound. Mass spectrum (ESI+): m/z=204 [M+H]+.

後処理

  1. filtrationThe precipitate is filtered off
  2. dissolutiondissolved in water and neutralized with 4 M HCl
  3. filtrationThe precipitate is filtered off
  4. dissolutiondissolved in dichloromethane
  5. dry with materiala small amount of methanol, and the solution is dried over Na2SO4
  6. concentrationconcentrated in vacuo
  7. customThe residue is triturated with diethylether

出典と根拠

ORDレコード
ord-5bd8e7b8bd6e406aaeec05900acc07b0
出典データセット
uspto-grants-2014_09
特許番号
US08822471B2

反応ノート

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