Dichloromethane → 3-(4-(3-Fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

反応式

[Cl:44][CH2:45][Cl:46].[F:1][C:2]1([c:13]2[cH:14][cH:15][c:16]([C:19]3=[N:20][O:21][C:22]([C:24]([F:25])([F:26])[F:27])([c:28]4[cH:29][c:30]([Cl:36])[c:31]([Cl:35])[c:32]([Cl:34])[cH:33]4)[CH2:23]3)[cH:17][cH:18]2)[CH2:3][N:4]([C:6]([O:7][C:8]([CH3:9])([CH3:10])[CH3:11])=[O:12])[CH2:5]1.[OH:37][C:38]([C:39]([F:40])([F:41])[F:42])=[O:43]>>[F:1][C:2]1([c:13]2[cH:14][cH:15][c:16]([C:19]3=[N:20][O:21][C:22]([C:24]([F:25])([F:26])[F:27])([c:28]4[cH:29][c:30]([Cl:36])[c:31]([Cl:35])[c:32]([Cl:34])[cH:33]4)[CH2:23]3)[cH:17][cH:18]2)[CH2:3][NH:4][CH2:5]1