Iodine → HCID 178516694、化合物

HRID 69043

反応式

HRID 69043 の反応式
C(=O)([O-])[O-].[K+].[K+].[OH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[CH:10][CH:9]=1.[I:18]I.C(=O)([O-])O.[Na+].S([O-])([O-])=O.[Na+].[Na+]>O.CN(C=O)C>[I:18][C:9]1[CH:10]=[N:11][C:12]2[C:17]([C:8]=1[OH:7])=[CH:16][CH:15]=[CH:14][CH:13]=2

参加物

8

反応物 5

HCID 807IodineHCID 11430Potassium CarbonateHCID 24437Sodium SulfiteHCID 516892Sodium BicarbonateHCID 178516385quinolin-4-ol

生成物 1

HCID 178516694HCID 178516694、化合物収率 96.4%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

Potassium carbonate (5.2 g) was added to a DMF solution (50 ml) of 4-hydroxy quinoline (5.0 g) and the mixture was stirred. Iodine (9.6 g) was added to the mixture, followed by stirring at room temperature for 3 hours. A saturated sodium hydrogencarbonate aqueous solution (73 ml) of 25% sodium sulfite, and water (50 ml) were added to the reaction mixture. The mixture was stirred and the precipitated insoluble matter was separated. The filtrate was washed with water and dried to give the title compound (9.0 g) as a white powder.

後処理

  1. stirringby stirring at room temperature for 3 hours
  2. stirringThe mixture was stirred
  3. customthe precipitated insoluble matter was separated
  4. washThe filtrate was washed with water
  5. customdried

出典と根拠

ORDレコード
ord-95f11b102de64b3bbe148233931cfbd0
出典データセット
uspto-grants-2014_09
特許番号
US08822453B2

関連ノート

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