Acetic Acid → 4-{[(2S)-2-fluoropropyl]oxy}piperidine
反応式
[F:1][C@@H:2]([CH3:11])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1.C(O)(=O)C>CO.[Pd]>[F:1][C@@H:2]([CH3:11])[CH2:3][O:4][CH:5]1[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1参加物
5
実験手順
2.2 g of 4-{[(2S)-2-fluoropropyl]oxy}pyridine was added to a solution of 22 mL of acetic acid in 22 mL of methanol, and 500 mg of 10% palladium on carbon (wet type) was added thereto under an argon atmosphere. The mixture was stirred at room temperature overnight under a hydrogen atmosphere of 3 atm. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (chloroform/methanol) to obtain 988 mg of 4-{[(2S)-2-fluoropropyl]oxy}piperidine.
後処理
- additionwas added
- filtrationThe reaction mixture was filtered through celite
- concentrationthe filtrate was concentrated under reduced pressure
- customThe residue was purified by basic silica gel column chromatography (chloroform/methanol)
出典と根拠
- ORDレコード
- ord-5bcb731dbce54b409b27b111188b01a7
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08822448B2
反応ノート
読み込み中…