Methylhydrazine → (E)-(2,4,6-trifluorophenyl)methylidenehydrazine

HRID 69140

反応式

HRID 69140 の反応式
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[C:6]([F:11])[C:3]=1[CH:4]=O.C[NH:13][NH2:14]>CCOCC>[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[C:6]([F:11])[C:3]=1/[CH:4]=[N:13]/[NH2:14]

参加物

4

反応物 2

HCID 6061MethylhydrazineHCID 5218452,4,6-Trifluorobenzaldehyde

生成物 1

HCID 57917272(E)-(2,4,6-trifluorophenyl)methylidenehydrazine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

2,4,6-Trifluoro-benzaldehyde (x) (4.5 g, 27.3 mmol) was dissolved in Et2O, methylhydrazine was added (1.43 mL, 27.3 mmol) and the RM was stirred overnight. The solvent was evaporated and the solid residue was suspended in a mixture of pentane and EtOAc to afford after filtration the title compound as a bright yellow crystalline solid (tR 4.95 min (conditions 3), MH+=198.1).

後処理

  1. customThe solvent was evaporated
  2. additionthe solid residue was suspended in a mixture of pentane and EtOAc
  3. customto afford
  4. filtrationafter filtration the title compound as a bright yellow crystalline solid (tR 4.95 min (conditions 3), MH+=198.1)

出典と根拠

ORDレコード
ord-cd338e979c4d47d48408e78b4dc0922f
出典データセット
uspto-grants-2014_09
特許番号
US08822468B2

関連ノート

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