Butanal → 1,1-Di-(5-fluoroindol-3-yl)-butane
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[CH:11](=O)[CH2:12][CH2:13][CH3:14]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]([C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=2)[NH:7][CH:6]=1)[CH2:12][CH2:13][CH3:14]参加物
3
実験手順
This was prepared in the same way as described in example 2/2 starting from 5-fluoroindole and butyraldehyde. The reaction, however, was heated under reflux for 24 hours. The end product was isolated and purified by chromatography on an SiO2 column using a hexane:ethyl ether gradient ranging from 7:3 to 4:6 as the eluent. Yield 45%.
後処理
- customThis was prepared in the same way
- customThe reaction
- temperaturehowever, was heated
- temperatureunder reflux for 24 hours
- customThe end product was isolated
- custompurified by chromatography on an SiO2 column
出典と根拠
- ORDレコード
- ord-40492c21a69f46b88fd0fa2d519864ca
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07084166B2
反応ノート
読み込み中…