Butanal → 1,1-Di-(5-fluoroindol-3-yl)-butane

HRID 6942

反応式

HRID 6942 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[CH:11](=O)[CH2:12][CH2:13][CH3:14]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]([C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=2)[NH:7][CH:6]=1)[CH2:12][CH2:13][CH3:14]

参加物

3

反応物 2

HCID 261ButanalHCID 678615-Fluoroindole

生成物 1

HCID 220193091,1-Di-(5-fluoroindol-3-yl)-butane収率 45%

実験手順

This was prepared in the same way as described in example 2/2 starting from 5-fluoroindole and butyraldehyde. The reaction, however, was heated under reflux for 24 hours. The end product was isolated and purified by chromatography on an SiO2 column using a hexane:ethyl ether gradient ranging from 7:3 to 4:6 as the eluent. Yield 45%.

後処理

  1. customThis was prepared in the same way
  2. customThe reaction
  3. temperaturehowever, was heated
  4. temperatureunder reflux for 24 hours
  5. customThe end product was isolated
  6. custompurified by chromatography on an SiO2 column

出典と根拠

ORDレコード
ord-40492c21a69f46b88fd0fa2d519864ca
出典データセット
uspto-grants-2006_08
特許番号
US07084166B2

関連ノート

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