Butanal → 1,1-Di-(7-azaindol-3-yl)-butane
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[CH:3]=[CH:2]1.[CH:10](=O)[CH2:11][CH2:12][CH3:13]>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[C:3]([CH:10]([C:3]2[C:4]3[C:9](=[N:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)[CH2:11][CH2:12][CH3:13])=[CH:2]1参加物
3
実験手順
ST 1436 was prepared as described in example 2/2 from 7-azaindole and butyraldehyde. The reaction, however, was heated under reflux for 48 hours. The end product was isolated and purified chromatographically on a silica column eluting with a CH2Cl2:CH3COCH3 gradient ranging from 9:1 to 4:6. Yield 15%.
後処理
- customST 1436 was prepared
- customThe reaction
- temperaturehowever, was heated
- temperatureunder reflux for 48 hours
- customThe end product was isolated
- custompurified chromatographically on a silica column
- washeluting with a CH2Cl2
出典と根拠
- ORDレコード
- ord-7e699b14c36a4cb1ab9bfad78d80f704
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07084166B2
反応ノート
読み込み中…