Methanesulfonyl chloride → (S)-1-(tetrahydrofuran-2-yl)methyl methanesulfonate
反応式
[S:1](Cl)([CH3:4])(=[O:3])=[O:2].[O:6]1[CH2:10][CH2:9][CH2:8][C@H:7]1[CH2:11][OH:12]>N1C=CC=CC=1>[O:6]1[CH2:10][CH2:9][CH2:8][C@H:7]1[CH2:11][O:12][S:1]([CH3:4])(=[O:3])=[O:2]参加物
4
実験手順
Mesylchloride (12.1 g) was added to a mixture of (S)-1-(Tetrahydro-furan-2-yl)-methanol (10.0 g) and pyridine (55 mL) at −15° C. and stirred for 1.5 hours at room temperature. The mixture was poured into ice water and extracted with ethyl acetate. The organic phase was washed with a solution of potassium hydrogensulfate (20%) and with a solution of saturated sodium hydrogencarbonate, dried over magnesium sulfate and concentrated.
後処理
- extractionextracted with ethyl acetate
- washThe organic phase was washed with a solution of potassium hydrogensulfate (20%) and with a solution of saturated sodium hydrogencarbonate
- dry with materialdried over magnesium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-c239c99e0dac47eabc6971ad83b5e709
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08822495B2
反応ノート
読み込み中…