Hydrogen Bromide → 6-Hydroxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one

反応式

C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[N:8]([C:14]1[CH:19]=[CH:18][C:17]([N:20]3[CH2:26][CH2:25][CH2:24][N:23]([CH3:27])[CH2:22][CH2:21]3)=[CH:16][CH:15]=1)[CH2:7][CH2:6]2.Br>>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[N:8]([C:14]1[CH:15]=[CH:16][C:17]([N:20]3[CH2:26][CH2:25][CH2:24][N:23]([CH3:27])[CH2:22][CH2:21]3)=[CH:18][CH:19]=1)[CH2:7][CH2:6]2

参加物

反応物 2

HCID 260Hydrogen Bromide

HCID 689902646-Methoxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one

生成物 1

HCID 689935356-Hydroxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one

実験手順

6-Methoxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one was reacted with 48% HBr according to Method L1. In this way the product was obtained with molecular weight 351.45 (C21H25N3O2); MS (ESI): 352 (M+H+).

後処理

customIn this way the product was obtained with molecular weight 351.45 (C21H25N3O2)

出典と根拠

ORDレコード: ord-aea17000532c439b8400be4b4ac4b880
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08822495B2

反応ノート

読み込み中…