Water → 5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one

HRID 69502

反応式

HRID 69502 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH2:6][CH2:5]2.[O:12]1[CH2:16][CH2:15][CH2:14][C@@H:13]1[CH2:17]OS(C)(=O)=O.O>CN(C=O)C>[O:12]1[CH2:16][CH2:15][CH2:14][C@@H:13]1[CH2:17][O:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH2:6][CH2:5]2

参加物

5

反応物 3

HCID 962WaterHCID 2331475-Hydroxy-1-indanoneHCID 18649742HCID 18649742、化合物

生成物 1

HCID 689893065-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 5-hydroxyindanone (80 mg) and methanesulfonic acid (R)-1-(tetrahydrofuran-2-yl)methyl ester (107 mg) in DMF (1 mL) was stirred at 70° C. for 16 h. After adding water it was extracted with ether, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel. In this way the product was obtained with molecular weight 232.28 (C14H16O3); MS (ESI): 233 (M+H+).

後処理

  1. extractionwas extracted with ether
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated
  4. customThe residue was chromatographed on silica gel
  5. customIn this way the product was obtained with molecular weight 232.28 (C14H16O3)

出典と根拠

ORDレコード
ord-7f3e6357e7c0499d9f9a3072dd89921e
出典データセット
uspto-grants-2014_09
特許番号
US08822495B2

関連ノート

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