化工社化工社 化学情報印刷レポート · 研究参考用
Water → 5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 5-Hydroxy-1-indanone | HCID 233147 | — |
| 反応物 | HCID 18649742 | HCID 18649742 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one | HCID 68989306 | — |
反応手順
A solution of 5-hydroxyindanone (80 mg) and methanesulfonic acid (R)-1-(tetrahydrofuran-2-yl)methyl ester (107 mg) in DMF (1 mL) was stirred at 70° C. for 16 h. After adding water it was extracted with ether, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel. In this way the product was obtained with molecular weight 232.28 (C14H16O3); MS (ESI): 233 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822495B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-7f3e6357e7c0499d9f9a3072dd89921e |
| 出典メモ | uspto-grants-2014_09 |