反应详情

A solution of 5-hydroxyindanone (80 mg) and methanesulfonic acid (R)-1-(tetrahydrofuran-2-yl)methyl ester (107 mg) in DMF (1 mL) was stirred at 70° C. for 16 h. After adding water it was extracted with ether, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel. In this way the product was obtained with molecular weight 232.28 (C14H16O3); MS (ESI): 233 (M+H+).

1. extractionwas extracted with ether
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated
4. customThe residue was chromatographed on silica gel
5. customIn this way the product was obtained with molecular weight 232.28 (C14H16O3)