HCID 17948959、化合物 → 4-(2,2-Difluoroethyl)pyrrolidin-2-one
反応式
[F:1][C:2]([F:10])=[CH:3][CH:4]1[CH2:8][NH:7][C:6](=[O:9])[CH2:5]1>[Pd].CO>[F:1][CH:2]([F:10])[CH2:3][CH:4]1[CH2:8][NH:7][C:6](=[O:9])[CH2:5]1参加物
4
実験手順
A solution of 4-(2,2-difluoroethenyl)pyrrolidin-2-one a1 (2.8 g, 18.77 mmol, 1 eq) and palladium on charcoal (10% Wt, 300 mg) in methanol (500 ml) is stirred overnight under an hydrogen atmosphere (40 psi) at room temperature. The reaction mixtured is filtered over celite and the solvent is removed under reduced pressure to afford 4-(2,2-difluoroethyl)pyrrolidin-2-one a11 which can be used in the next step without any further purification.
後処理
- customThe reaction
- filtrationmixtured is filtered over celite
- customthe solvent is removed under reduced pressure
出典と根拠
- ORDレコード
- ord-f18b7aa74a03440a9e73c6b6bacb5116
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08822508B2
反応ノート
読み込み中…