Tetrahydrofuran → 3,4-Difluoro-2-[[2-fluoro-4-(trimethylsilylethynyl)phenyl]amino]benzoic acid

反応式

[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:28][Si:29]([N-:30][Si:31]([CH3:32])([CH3:33])[CH3:34])([CH3:35])[CH3:36].[F:15][c:16]1[c:17]([C:18](=[O:19])[OH:20])[cH:21][cH:22][c:23]([F:26])[c:24]1[F:25].[F:1][c:2]1[c:3]([NH2:4])[cH:5][cH:6][c:7]([C:9]#[C:10][Si:11]([CH3:12])([CH3:13])[CH3:14])[cH:8]1.[Li+:27]>>[F:1][c:2]1[c:3]([NH:4][c:16]2[c:17]([C:18](=[O:19])[OH:20])[cH:21][cH:22][c:23]([F:26])[c:24]2[F:25])[cH:5][cH:6][c:7]([C:9]#[C:10][Si:11]([CH3:12])([CH3:13])[CH3:14])[cH:8]1