(3R,4R)-benzyl 3-(tert-butoxycarbonylamino)-4-(methylsulfonyloxy)piperidine-1-carboxylate → HCID 58386792、化合物
反応式
C([O:5][C:6]([NH:8][C@H:9]1[C@H:14](OS(C)(=O)=O)[CH2:13][CH2:12][N:11]([C:20]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:21])[CH2:10]1)=[O:7])(C)(C)C>N1C=CC=CC=1>[O:7]=[C:6]1[NH:8][C@@H:9]2[CH2:10][N:11]([C:20]([O:22][CH2:23][C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)=[O:21])[CH2:12][CH2:13][C@@H:14]2[O:5]1参加物
3
実験手順
A solution of (3R,4R)-benzyl 3-(tert-butoxycarbonylamino)-4-(methylsulfonyloxy)piperidine-1-carboxylate in pyridine (0.16 M) was heated to 120° C. in the microwave for 10 minutes. The solution was then concentrated to almost dryness and the forming solid was filtered to give the desired product. The filtrate was further purified via silica gel column chromatography eluting with ethyl acetate (100%) to give the product in 75% combined yield. LCMS (m/z): 277.1 (MH+), LC Rt=2.33 min.
後処理
- concentrationThe solution was then concentrated to almost dryness