3-Fluoro-5-bromobenzaldehyde oxime → 3-Bromo-5-fluorobenzonitrile

HRID 7002

反応式

HRID 7002 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:11])[CH:10]=1)[CH:5]=[N:6]O>C(#N)C.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:11])[CH:10]=1)[C:5]#[N:6]

参加物

4

反応物 1

HCID 738580123-Fluoro-5-bromobenzaldehyde oxime

生成物 1

HCID 27833303-Bromo-5-fluorobenzonitrile収率 89.3%

試薬・触媒・溶媒 2

HCID 8895Cupric acetate触媒HCID 6342Acetonitrile溶媒

実験手順

The above oxime (3.76 g, 17.24 mmol) and copper (II) acetate (370 mg) were dissolved in acetonitrile (100 cm3) under nitrogen and heated under reflux. After 5 h, the mixture was evaporated, the residue taken into EtOAc, washed with sulfuric acid (1N), water, brine, dried (MgSO4) and evaporated to give 3-fluoro-5-bromobenzonitrile (3.08 g, 15.39 mmol, 89%) which was used without further purification.

後処理

  1. temperatureheated
  2. temperatureunder reflux
  3. customthe mixture was evaporated
  4. washwashed with sulfuric acid (1N), water, brine
  5. dry with materialdried (MgSO4)
  6. customevaporated

出典と根拠

ORDレコード
ord-127f208a746641c1877f78d37d4f625e
出典データセット
uspto-grants-2006_08
特許番号
US07084168B2

関連ノート

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