Ethanol, 2-chloro-, 1-(4-methylbenzenesulfonate) → 5-{4-[(2-Chloroethyl)oxy]phenyl}-2-thiophenecarboxamide

温度

57.5 °C

To a suspension of ammonium chloride (2.12 g, 39.6 mmol) in 10 ml of toluene at 5° C. was added dropwise 19.8 ml of 2M trimethylaluminum in toluene solution. The mixture was stirred for 2 h at the room temperature and ethyl 5-(4-hydroxyphenyl)-2-thiophene carboxylate (Intermediate KK-1-1) (1.98 g, 7.03 mmol) was added. The resulting mixture was heated at 55-60° C. for 15 h, cooled to 5° C. and quenched with ethanol (10 ml). All solvents were removed in vacuo and the residue was treated with 80 ml of 0.5M HCl solution. A yellow solid was collected by filtration, washed with water and air-dried (1.64 g). The product was added to a mixture of 2-chloroethyl p-toluenesulfonate (4.07 ml, 22.5 mmol) and potassium carbonate (3.11 g, 22.5 mmol) in 100 ml of acetonitrile. After heating at reflux for 40 h, the reaction mixture was filtered to remove the solids, concentrated to dryness in vacuo and purified by silica gel column chromatography using Hexanes and EtOAc to give the title compound as a light yellow solid.

1. additionwas added
2. temperaturecooled to 5° C.
3. customquenched with ethanol (10 ml)
4. customAll solvents were removed in vacuo
5. additionthe residue was treated with 80 ml of 0.5M HCl solution
6. filtrationA yellow solid was collected by filtration
7. washwashed with water
8. customair-dried (1.64 g)
9. temperatureAfter heating
10. temperatureat reflux for 40 h
11. filtrationthe reaction mixture was filtered
12. customto remove the solids
13. concentrationconcentrated to dryness in vacuo
14. custompurified by silica gel column chromatography

ORDレコード

ord-3e2683c486124a4c96c2957d818c48fc

出典データセット

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08822518B2