Dichloromethane → 3-(2,2,3,3,3-Pentafluoropropoxy)methyl-4-methyl-1-nitrobenzene

HRID 703344

反応式

HRID 703344 の反応式
[CH3:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[CH2:4]Cl.[F:13][C:14]([F:21])([C:17]([F:20])([F:19])[F:18])[CH2:15][OH:16].[OH-].[K+].ClCCl>CN(C)C=O>[F:13][C:14]([F:21])([C:17]([F:20])([F:19])[F:18])[CH2:15][O:16][CH2:4][C:3]1[CH:6]=[C:7]([N+:10]([O-:12])=[O:11])[CH:8]=[CH:9][C:2]=1[CH3:1]

参加物

6

反応物 4

HCID 6344DichloromethaneHCID 98722,2,3,3,3-PentafluoropropanolHCID 14797Potassium HydroxideHCID 1879522-(Chloromethyl)-1-methyl-4-nitrobenzene

生成物 1

HCID 150701683-(2,2,3,3,3-Pentafluoropropoxy)methyl-4-methyl-1-nitrobenzene

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

In 16.5 ml of dimethylformamide, 5.00 g (0.027 mol) of 2-methyl-5-nitrobenzyl chloride and 21.3 g (0.135 mol) of 2,2,3,3,3-pentafluoropropanol were dissolved. The solution was then added with 2.29 g (0.041 mol) of KOH pellets and stirred overnight. Dichloromethane was added and the precipitated salts were filtered out. The filtrate was acidified with dilute hydrochloric acid and then the solvents were distilled off.

後処理

  1. filtrationthe precipitated salts were filtered out
  2. distillationthe solvents were distilled off

出典と根拠

ORDレコード
ord-fe6198eb9b0a45a8ba52b72219df5ea0
出典データセット
uspto-grants-1991_01
特許番号
US04983209

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