Sodium Hydroxide → HCID 178458876、化合物

HRID 703360ノート

反応式

HRID 703360 の反応式
CC(C)([O-])C.[K+].[C:7]([C:11]1[C:12](=[O:25])[CH2:13][CH:14]([C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=2)[CH2:15][C:16]=1[OH:17])(=[O:10])[CH2:8][CH3:9].CS([C:30]1[CH:35]=[CH:34][C:33]([S:36]([CH3:39])(=[O:38])=[O:37])=[CH:32][N:31]=1)(=O)=O.[OH-].[Na+]>CS(C)=O>[C:7]([C:11]1[C:12](=[O:25])[CH2:13][CH:14]([C:18]2[CH:19]=[CH:20][C:21]([O:24][C:30]3[CH:35]=[CH:34][C:33]([S:36]([CH3:39])(=[O:38])=[O:37])=[CH:32][N:31]=3)=[CH:22][CH:23]=2)[CH2:15][C:16]=1[OH:17])(=[O:10])[CH2:8][CH3:9]

参加物

6

反応物 4

HCID 14798Sodium HydroxideHCID 131026752,5-Bis(methylsulfonyl)pyridineHCID 23665647Potassium tert-butoxideHCID 178458877HCID 178458877、化合物

生成物 1

HCID 178458876HCID 178458876、化合物

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

A solution of 3.3 g (0.029 mol) of potassium t-butoxide in 40 mL of dimethyl sulfoxide was treated with 3.5 g (0.013 mol) of 2-propionyl-3-hydroxy-5-(4-hydroxyphenyl)cyclohex-2-en-1-one at room temperature. The mixture was stirred for 10 minutes and 4.1 g (0.017 mol) of 2,5-bis(methylsulfonyl)pyridine was added. The resulting mixture was stirred for 1 hour, becoming dark and homogeneous. The mixture was poured into 200 mL of cold, dilute (0.1N) NaOH and washed with 50 mL of diethyl ether. The aqueous alkaline layer was removed and acidified (pH 2) with 1N HCl and the solution was extracted 4 times with 50 mL portions of ethyl acetate. The organic layers were combined and washed with an aqueous saturated NaCl solution, dried over MgSO4, filtered and the solvent removed by evaporation leaving a solid residue. Recrystallization of the residue from a 1:4 ethyl acetate/absolute ethanol mixture gave the above named product as a beige-white solid in a yield of 4.5 g (80 percent of theoretical). The product melted at 163°-164.5° C.; 1H NMR (CDCl3): δ 1.13 (t, 3H, CH3 --), 2.63-3.75 (m includes at 3.07 for CH3SO2 --, 7H ring protons and --CH2CH3), 7.03-7.42 (m, 5H, ArH's), 8.25 (dd, 1H, ArH), 8.77 (d, 1H, ArH), 18.2 (s, 1H, enol H).

後処理

  1. stirringThe resulting mixture was stirred for 1 hour
  2. additionThe mixture was poured into 200 mL of cold,
  3. washwashed with 50 mL of diethyl ether
  4. customThe aqueous alkaline layer was removed
  5. extractionthe solution was extracted 4 times with 50 mL portions of ethyl acetate
  6. washwashed with an aqueous saturated NaCl solution
  7. dry with materialdried over MgSO4
  8. filtrationfiltered
  9. customthe solvent removed by evaporation
  10. customleaving a solid residue
  11. customRecrystallization of the residue from a 1:4 ethyl acetate/absolute ethanol mixture
  12. customgave the

出典と根拠

ORDレコード
ord-e517b49c155542ed8930815415ce264e
出典データセット
uspto-grants-1991_01
特許番号
US04983211

反応ノート

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