Diethyl Ether → HCID 13548560、化合物

HRID 703443ノート

反応式

HRID 703443 の反応式
S(Cl)(Cl)=O.[O:5]=[C:6]1[CH:15]=[C:14]([CH2:16][C:17]([OH:19])=[O:18])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7]1.[CH3:20]COCC>CO>[O:5]=[C:6]1[CH:15]=[C:14]([CH2:16][C:17]([O:19][CH3:20])=[O:18])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7]1

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 24386Thionyl ChlorideHCID 47377352-(2-oxo-1,2-dihydroquinolin-4-yl)acetic acid

生成物 1

HCID 13548560HCID 13548560、化合物収率 80%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

95 g (0.8 mol) of thionyl chloride are added dropwise in the course of approximately 1 h to a stirred suspension of 60 g (0.295 mol) of 2-oxo-1,2-dihydro-4-quinolineacetic acid in 1 1 of methanol. The mixture is left overnight. The solvent is driven off and the residue obtained is dissolved in 300 ml of boiling methanol. After the mixture is cooled, 300 ml of ether are added. The solid is drained and then recrystallized in methanol. 51.5 g (80%) of methyl 2-oxo-1,2-dihydro-4-quinolineacetate, melting point 209°-210° C., are obtained

後処理

  1. customthe residue obtained
  2. temperatureAfter the mixture is cooled
  3. customrecrystallized in methanol

出典と根拠

ORDレコード
ord-06da27d9487f4fdfaa63a5c6f2454e5c
出典データセット
uspto-grants-1991_01
特許番号
US04983607

反応ノート

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