Benzyl Chloride → 1,3,4-Thiadiazol-2-amine, 5-((phenylmethyl)thio)-

HRID 703826

反応式

HRID 703826 の反応式
[NH2:1][C:2]1[S:3][C:4]([SH:7])=[N:5][N:6]=1.[OH-].[Na+].[CH2:10](Cl)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O.C(O)C>[NH2:1][C:2]1[S:3][C:4]([S:7][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:5][N:6]=1

参加物

6

反応物 3

HCID 7503Benzyl ChlorideHCID 14798Sodium HydroxideHCID 178509208HCID 178509208、化合物

生成物 1

HCID 992851,3,4-Thiadiazol-2-amine, 5-((phenylmethyl)thio)-収率 94%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

反応条件

温度
50 °C

実験手順

In a mixture of 40 ml of water and 45 ml of ethanol, 21.1 g of 2-amino-5-mercapto-1,3,4-thiadiazole and 6.9 g of sodium hydroxide were dissolved. To this solution, 19.6 g of benzyl chloride was added, and the mixture was stirred at 50° C. for 1 hour. After cooling, water was added to the reaction mixture, the formed precipitate was separated by filtration and washed with water and an ethanol/n-hexane (1:1) mixture respectively. The thus treated precipitate was dried under reduced pressure, and thus 32.5 g of 2-amino-5-benzylthio-1,3,4-thiadiazole was obtained. m.p. 159°-161° C. Yield 94%.

後処理

  1. dissolutionwere dissolved
  2. temperatureAfter cooling
  3. customthe formed precipitate was separated by filtration
  4. washwashed with water
  5. customThe thus treated precipitate was dried under reduced pressure

出典と根拠

ORDレコード
ord-384ab92d6add4c6d88eb0e2c8156c0e7
出典データセット
uspto-grants-1991_01
特許番号
US04985432

関連ノート

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