1-Naphthol → 2-(4-Chlorobutyryl)-1-naphthol

HRID 703886

反応式

HRID 703886 の反応式
[C:1]1([OH:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Cl:12][CH2:13][CH2:14][CH2:15][C:16](O)=[O:17].B(F)(F)F.CCOCC>O>[Cl:12][CH2:13][CH2:14][CH2:15][C:16]([C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:1]=1[OH:11])=[O:17]

参加物

5

反応物 3

HCID 70051-NaphtholHCID 8000Boron trifluoride etherateHCID 123004-Chlorobutanoic acid

生成物 1

HCID 156179222-(4-Chlorobutyryl)-1-naphthol収率 38.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of 1-naphthol (15.14 g, 0.105 mole), 4-chlorobutyric acid (9.90 mL, 0.100 mole), and boron trifluoride etherate (75 mL) was heated on a steam bath for 4 hours. The mixture was then treated slowly with 100 mL of water, and heating continued for 30 minutes. The mixture was poured into water, stirred, and the solution decanted. The residue was triturated with water, then crystallized from ethanol to provide the title compound (9.50 g, 38%) as a pale green solid, mp 73°-79°.

後処理

  1. temperaturewas heated on a steam bath for 4 hours
  2. temperatureheating
  3. customthe solution decanted
  4. customThe residue was triturated with water
  5. customcrystallized from ethanol

出典と根拠

ORDレコード
ord-f6f70456936c498884c9c366de5ebcb0
出典データセット
uspto-grants-1991_01
特許番号
US04985442

関連ノート

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