Dicyclohexylcarbodiimide → HCID 178442538、化合物

HRID 704286ノート

反応式

HRID 704286 の反応式
[C:1]([C:3]1([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH2:8][CH2:7][CH:6]([CH:9]2[CH2:14][CH2:13][CH:12]([OH:15])[CH2:11][CH2:10]2)[CH2:5][CH2:4]1)#[N:2].O1C2(CCC(C3CCC(=O)CC3)CC2)OCC1.S(C[N+]#[C-])(C1C=CC(C)=CC=1)(=O)=O.[Li+].CC([N-]C(C)C)C.C(Br)CCCCCC.[BH4-].[Na+].[CH2:71]([C@H:76]1[CH2:81][CH2:80][C@H:79]([C:82](O)=[O:83])[CH2:78][CH2:77]1)[CH2:72][CH2:73][CH2:74][CH3:75].C1(N=C=NC2CCCCC2)CCCCC1>CN(C)C1C=CN=CC=1.C(Cl)Cl>[C:1]([C:3]1([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH2:8][CH2:7][CH:6]([CH:9]2[CH2:14][CH2:13][CH:12]([O:15][C:82]([C@H:79]3[CH2:80][CH2:81][C@H:76]([CH2:71][CH2:72][CH2:73][CH2:74][CH3:75])[CH2:77][CH2:78]3)=[O:83])[CH2:11][CH2:10]2)[CH2:5][CH2:4]1)#[N:2]

参加物

11

反応物 8

HCID 10868DicyclohexylcarbodiimideHCID 123691-BromoheptaneHCID 161915Tosylmethyl isocyanideHCID 8109134-(1,4-Dioxa-spiro(4.5)dec-8-yl)-cyclohexanoneHCID 2724682Lithium diisopropylamideHCID 4311764Sodium borohydrideHCID 200761544-Cyano-4-heptyl-4'-hydroxybicyclohexaneHCID 178444557HCID 178444557、化合物

生成物 1

HCID 178442538HCID 178442538、化合物

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒2 回

実験手順

1 g of 4-dimethylaminopyridine and 30.3 g (0.1 mole) of 4-cyano-4-heptyl-4'-hydroxybicyclohexane (obtainable from 4-(1,4-dioxaspiro[4,5]dec-8-yl)-cyclohexanone by introduction of the nitrile group with tosylmethyl isocyanide (TOSMIC), alkylation with LDA (diisopropylamine/butyl-lithium) and heptyl bromide, detachment of the keto-protective group, reduction of the ketone with NaBH4 to the alcohol and separation of the isomers) are added to 19.8 g (0.1 mole) of trans-4-pentylcyclohexanecarboxylic acid in 75 ml of CH2Cl2, with stirring. A solution of 27.7 g (0.105 mole) of dicyclo-hexylcarbodiimide in 50 ml of methylene chloride is added dropwise at 0°, while controlling the temperature, and the mixture is then stirred at room temperature for a further hour. The urea precipitated is separated off and the methylene chloride phase is washed with dilute HCl and saturated NaHCO3 solution and dried. The product is then purified by filtration over a short silica gel column and by crystallisation. 4-Cyano-4-heptyl-4'-(trans-4-pentylcyclohexylcarbonyloxy)-bicyclohexane is obtained.

後処理

  1. stirringthe mixture is then stirred at room temperature for a further hour
  2. customThe urea precipitated
  3. customis separated off
  4. washthe methylene chloride phase is washed with dilute HCl and saturated NaHCO3 solution
  5. customdried
  6. filtrationThe product is then purified by filtration over a short silica gel column and by crystallisation

出典と根拠

ORDレコード
ord-13dc750527bf44dbada3076a853a38b0
出典データセット
uspto-grants-1991_01
特許番号
US04985583

反応ノート

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