4-(Bromomethyl)benzonitrile → trans-2-[(4-Chlorobenzenesulfonyl)-(4-cyano-benzyl)-amino]-cyclohexanecarboxylic acid amide

HRID 7043

反応式

HRID 7043 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]2[C:18]([NH2:20])=[O:19])(=[O:10])=[O:9])=[CH:4][CH:3]=1.Br[CH2:22][C:23]1[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:22][C:23]2[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=2)[C@@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]2[C:18]([NH2:20])=[O:19])(=[O:9])=[O:10])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 869964-(Bromomethyl)benzonitrileHCID 69656245trans-2-(4-Chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide

生成物 1

HCID 11247468trans-2-[(4-Chlorobenzenesulfonyl)-(4-cyano-benzyl)-amino]-cyclohexanecarboxylic acid amide収率 43%

実験手順

The titled compound was prepared in 43% yield from trans-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide and 4-bromomethyl-benzonitrile according to the procedure described in Example 11: 1H NMR (DMSO-d6) δ 7.71(m, 4 H), 7.53 (m, 4 H), 7.29 (s, 1 H), 6.76 (s, 1 H), 4.44 (AB2,2 H,Δv=16,Jab=84 Hz), 3.96 (m, 1 H), 1.80 (m, 1 H), 1.57 (m, 3 H), 1.17 (m, 5 H); MS m/e 432.01 (M+H)+.

出典と根拠

ORDレコード
ord-386f48eba40548c182cc938b1a8dd1e7
出典データセット
uspto-grants-2006_08
特許番号
US07084178B2

関連ノート

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