Hydrogen Bromide → 1-(3-Bromopropyl)-4-methylbenzene
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10]O)=[CH:4][CH:3]=1.[BrH:12]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][Br:12])=[CH:4][CH:3]=1参加物
3
実験手順
3-(4-Methylphenyl)propanol (2.13 g) was heated in 7 ml of 47% aqueous hydrobromic acid under reflux for 5 hours. The solvent was then distilled off under reduced pressure and, after addition of water, the residue was extracted with ether. The organic layer was washed with saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was distilled under reduced pressure to give 1.75 g of 3-(4-methylphenyl)propyl bromide. Boiling point: 65° C./0.7 mmHg.
後処理
- temperatureunder reflux for 5 hours
- distillationThe solvent was then distilled off under reduced pressure
- additionafter addition of water
- extractionthe residue was extracted with ether
- washThe organic layer was washed with saturated aqueous solution of sodium chloride
- dry with materialdried over anhydrous magnesium sulfate
- concentrationconcentrated under reduced pressure
- distillationThe residue was distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-fd1850b06e4b44c79be4d76efcef089e
- 出典データセット
- uspto-grants-1991_01
- 特許番号
- US04987132
反応ノート
読み込み中…