Sodium Iodide → 1-(3-Iodopropyl)-4-methoxybenzene

HRID 704402

反応式

HRID 704402 の反応式
CS(O[CH2:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)(=O)=O.[I-:17].[Na+]>CC(C)=O>[CH3:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([CH2:8][CH2:7][CH2:6][I:17])=[CH:10][CH:11]=1

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 116659383-(4-Methoxyphenyl)propyl methanesulfonate

生成物 1

HCID 140406651-(3-Iodopropyl)-4-methoxybenzene収率 93%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 6.30 g of 3-(4-methoxyphenyl)propyl methanesulfonate and 11.1 g of sodium iodide in 100 ml of acetone was refluxed for 15 hours. The reaction mixture was concentrated under reduced pressure and, after addition of water, the residue was extracted with ether. The organic layer was washed with saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 6.62 g of 3-(4-methoxyphenyl)propyl iodide.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionafter addition of water
  3. extractionthe residue was extracted with ether
  4. washThe organic layer was washed with saturated aqueous solution of sodium chloride
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-169f61b8947e4eea92bcc75a0d45316c
出典データセット
uspto-grants-1991_01
特許番号
US04987132

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