Hydrogen Bromide → (4-Bromo-2-methylbutan-2-yl)benzene
反応式
[CH3:1][C:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([CH3:6])[CH2:3][CH2:4]O.O.[BrH:14]>>[Br:14][CH2:4][CH2:3][C:2]([CH3:6])([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:1]参加物
4
実験手順
3-Metyl-3-phenylbutanol (0.82 g) was refluxed in 47% hydrobromic acid (5 ml) under heating for 7 hours. To the reaction solution was added water and the solution was extracted with ether. After washing with a saturated aqueous solution of sodium chloride, the ether layer was dried over anhydrous magnesium sulfate, and the residue was then subjected to silica gel column chromatography. Elution with a hexane - ethyl acetate 10:1) mixture gave 1.02 of 1-bromo-3-methyl-3-phenylbutane.
後処理
- temperatureunder heating for 7 hours
- extractionthe solution was extracted with ether
- washAfter washing with a saturated aqueous solution of sodium chloride
- dry with materialthe ether layer was dried over anhydrous magnesium sulfate
- washElution with a hexane - ethyl acetate 10:1) mixture
出典と根拠
- ORDレコード
- ord-bdbe03d1380d49ac83c2d3cd7684d2ef
- 出典データセット
- uspto-grants-1991_01
- 特許番号
- US04987132
反応ノート
読み込み中…