HCID 53436965、化合物 → HCID 54162915、化合物
反応式
[C:1]([C:3]([C:7]([O:9][CH3:10])=[O:8])=[CH:4]OC)#[N:2].[N:11]1([CH:16]=[CH:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:15][CH2:14][CH2:13][CH2:12]1>O1CCCC1>[C:1]([C:3]([C:7]([O:9][CH3:10])=[O:8])=[CH:4][C:17]1[CH2:18][CH2:19][CH2:20][CH2:21][C:16]=1[N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)#[N:2]参加物
4
実験手順
1-Cyano-2methoxy-1-methoxycarbonyl-ethene (8.5 g, 0.06 mol) in tetrahydrofuran (60 ml) was chilled to -25° C. At this temperature, a solution of 1-pyrrolidino-hexene (9.1 g, 0.06 mol) in tetrahydrofuran (30 ml) was added dropwise. Cooling was then stopped and the reaction mixture was allowed to warm up to room temperature. The solution was then stirred for 1 hour and then evaporated. The resulting gum was triturated with isopropanol and the resulting solid material collected by vacuum filtration. After drying, yellowish crystals of 1-cyano-1-methoxycarbonyl-2-(2-pyrrolidino-cyclohexenyl)-ethene (9.5 g, 60.9% of theoretical yield; m.pt. 133° C.-134° C.) Were obtained. The compound migrated in tlc uniformly and was used for the next step without further purification.